Study supports extrapleural pneumonectomy to treat select mesothelioma patients

24 Aug 2009 by under News, Research/Treatment

The results of a study published recently in The Journal of Thoracic and Cardiovascular Surgery supports the use of extrapleural pneumonectomy-based multimodal therapy in carefully selected patients with malignant pleural mesothelioma. The Journal is published by The American Association for Thoracic Surgery.

According to the summary, the objective of the study was to evaluate the perioperative and long-term outcomes associated with extrapleural pneumonectomy for patients with malignant pleural mesothelioma. Pleural mesothelioma affects the lining of the chest cavity and lungs. Other forms of mesothelioma include pericardial, which affects the lining of the heart and is extremely rare; and peritoneal, which affects the lining of the abdomen. Mesothelioma is atributed almost exclusively to asbestos exposure.

According to the Multimedia Manual of Cardiothoracic Surgery, extrapleural pneumonectomy was introduced in the 1940s for the treatment of extensive infections of the lung and pleural space. Over the past 20 years, the extrapleural pneumonectomy technique has been modified and applied to the treatment of locally advanced malignant pleural mesothelioma, achieving substantial reductions in mortality. The surgery involves the removal of the lung with visceral and parietal pleurae, pericardium and diaphragm.

Researchers selected 70 patients between October 1994 and April 2008 to undergo the procedure. Prognostic factors included age, gender, side of disease, asbestos exposure, histology, positron emission tomography, date of surgery, neoadjuvant chemotherapy, completeness of cytoreduction, lymph node involvement, peioperative morbidity, adjuvant radiotherapy and pemetrexed-based chemotherapy.

The mean age of patients was 55 years. The median survival was 20 months, with a 3-year survival of 30 percent. Analyses showed improved survival for patients with asbestos exposure, negative lymph node involvement, and receipt of adjuvant radiation or postoperative pemetrexed-based chemotherapy.

The study was conducted by physicians from the University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital; The Baird Institute for Applied Heart and Lung Surgical; Department of Medical Oncology, Sydney Cancer Center, Royal Prince Alfred Hospital; and Department of Radiation Oncology, Sydney Cancer Center, Royal Prince Alfred Hospital; all in Sydney, .

6 Responses to “Study supports extrapleural pneumonectomy to treat select mesothelioma patients”

  1. Mike Crill Missoula,Mt

    I do have a question for you.In Libby,Mt, where over 2000 people are living/suffering with and dying from asbestos exposure/all diagnosed.Now, we are all told that 90% of all diagnosed in Libby, have Plural Thickening/Plague.We are also told that a Meso epidemic is on the horizon within the next 10 to 30 years.And I assume that epidemic IS the 90%/2000 people of Libby Mt.I am one of those with Thickening.As a victim,we live everyday for the day we are told we have Meso.It is not how but when…if we don’t die from something else first.Yah, what a life huh??? I am wondering why we have to be diagnosed with Meso befor anyone will help us(legally).As a walking dead,do all Meso people have Plural thickening/Plaque before Meso? Or does Meso happen all by itself?James Hardie needs to hang along with WR Grace and a whole lot of people who knowingly did this to us…all of us.Thank you myMeso for what you do and for whom as we all learn the truth about what has happened to us.Our children also must be the priority to protect.And Libby Mt is sold as safe.What’s wrong with that picture??? Continued deadly exposure to new innocent families being lied to that Libby is safe.The killings have not stopped.I tell all who will listen to stay away from Libby Mt.I save lives while EPA kills life.Where did we go so wrong here as human life seems to be worthless.Atleast in Libby Mt.God Bless all of you out their facing this nitemare.The only thing we have to do is protect those we leave behind…our kids.Thank you.

  2. florea

    Very good info !

  3. florea

    Very good info !

  4. Painting

    nice to hear

  5. mesothelioma_lawyer_ohio

    This is the great blog, I'm reading them for a while, thanks for the post

  6. Mesothelioma

    Some pleural mesothelioma patients opt to participate in clinical trials to take advantage of up-and-coming treatments in an attempt to improve their life expectancy.