IMRT may be more effective mesothelioma radiation treatment

18 May 2017 by Sarah Mahan under Research/Treatment
RadiationTherapy 100x100 IMRT may be more effective mesothelioma radiation treatment

Credit: U.S. Air Force photo/ Staff Sgt. Liliana Moreno

therapy, or radiotherapy, is often included in the multi-modal treatment of mesothelioma, a deadly cancer caused by the inhalation or ingestion of asbestos. Because mesothelioma affects the lining of organs and those linings are in close contact with other vital tissues, runs the risk of damaging surrounding healthy organs. New research has shown a different type of therapy may be more effective on pleural mesothelioma, which affects the lining of the lungs, compared to standard conformal by reducing the risk of damaging healthy tissue.

Researchers at Gazi University in Turkey determined intensity-modulated radiotherapy (IMRT) was found to be more effective and less dangerous than standard conformal , which shapes beams to match the shape of a tumor, according to Mesothelioma Research News.

Researchers exposed the tumors of 12 patients with malignant pleural mesothelioma to seven to nine beams of IMRT at different angles at a dose ranging from 1.8 to 50.4 Gy on one lung and to standard on the other.

“Intensity-modulated therapy was statistically superior in target coverage and dose homogeneity,” Sukran Ulger, MD, a oncologist and part of the medical faculty at Gazi University, said in a press release.

The researchers found IMRT exposed tumors to higher doses of while sparing more surrounding healthy tissue than compared to standard radiotherapy. They also found IMRT was more evenly distributed and covered the target tissue more completely than conformal radiotherapy, according to the news source. The study states, “To overcome high local-regional recurrence, IMRT appears to be the only option for irradiating the target volume with an efficient dose.”

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