Bullfrog protein may be used as mesothelioma treatment

8 Jun 2017 by under Research/Treatment

640px Pyxicephalus adspersus Boston Aquarium 100x100 Bullfrog protein may be used as mesothelioma treatment Standard-of-care treatments for patients often include , usually with a combination of Alimta and Platinol. However, no cure for mesothelioma currently exists and treatments often only extended patients’ lives by months. For those reasons, researchers continue searching for better treatment alternatives. They often turn to plants and animals for these alternatives and have recently turned to amphibians for clues.

Researchers believe they have isolated a protein found in bullfrogs that may prove to be a legitimate treatment option for mesothelioma, according to Mesothelioma Research News. The protein, sialic acid-binding lectin (cSBL), “has a toxic effect on cells and a preference to recognize, bind, and enter cancer cells rather than normal cells,” the news source reports.

Japanese researchers aimed to compare the bullfrog protein to the standard-of-care for mesothelioma, a combination of Alimta and Platinol. They found the protein exhibited a higher cancer cell selection than the standard drugs, and when given with Alimta, the protein demonstrated a higher toxicity to mesothelioma cells than the normal combination of drugs. Individually, Altima works by slowing down cell division and stops the creation of new cancer cells, and  cSBL works by stopping protein formation by degrading a cell’s genetic material.

“Pemetrexed (Alimta) + cSBL exhibited a strong synergistic effect that was comparable or even superior to the standard regimen of pemetrexed + cisplatin (Platinol). We propose that the synergistic effect results from the combination of the cytostatic effect of pemetrexed and the cytotoxic effect of cSBL,” researchers wrote. “Therefore, cSBL has therapeutic potential for mesothelioma.”


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