Compound found in broccoli could help fight mesothelioma

5 Jul 2017 by Sarah Mahan under Research/Treatment

Broccoli666 100x100 Compound found in broccoli could help fight mesotheliomaEveryone says to eat your veggies to stay healthy. However, they probably didn’t realize those veggies could contain mesothelioma cancer-fighting benefits.

A recent study found the compound sulforaphane, produced in cruciferous vegetables like broccoli, Brussel sprouts, cauliflower and cabbage, could boost the number of mesothelioma cells killed with chemotherapy and cause minimal side effects, according to Surviving Mesothelioma. The researchers studied the benefits of the compound in conjunction with using cisplatin, popularly used as part of multimodal treatment for the deadly cancer that can affect the lining of the heart, lungs or abdomen and take decades to become known.

“Combination treatment with the two compounds exhibited synergistic growth‑inhibiting and apoptosis‑promoting [cell death] activities, as demonstrated by a series of proapoptotic events,” the researchers wrote in the journal Molecular Medicine Reports.

The presence of the two compounds caused a cascade of degenerative reactions in the mesothelioma cells. However, cancer cells are notorious for managing to protect themselves. One such method breaks down cell components so they can be reused to form new cancer cells. The researchers used another compound to artificially stifle the breakdown, known as autophagy, which further increased their effectiveness. “The results of the present study provide a rationale for targeting cytoprotective autophagy as a potential therapeutic strategy for malignant mesothelioma,” the report concludes.

And while it’s always important to eat your veggies, the researchers note that the anticancer benefits demonstrated in the study are not obtainable through just eating your greens.

 

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