10 gene mutations linked to mesothelioma predisposition

11 Jul 2017 by Sarah Mahan under Research/Treatment

598px Chemotherapy vials 3 100x100 10 gene mutations linked to mesothelioma predisposition Researchers associate a BAP1 gene mutation with a predisposition to several types of cancers, including mesothelioma. In a new study, Italian researchers suggest BAP1 is not the only gene mutation that can cause the deadly cancer.

Ten different genetic variants have been found to potentially play a role in the development of pleural or peritoneal mesothelioma, which affect the lining of the lungs and stomach respectively, according to Surviving Mesothelioma. The researchers studied 94 genes known to predispose people to cancer  in 93 pleural mesothelioma patients. The genes studied can be passed from one generation to the next. They found “in nearly one in ten mesothelioma patients studied, their bodies were not capable of efficiently repairing the DNA damage caused by their exposure to asbestos. This inability eventually led some cells to become malignant and produce mesothelioma tumors,” according to the news source.

Though the research helps determine why certain people contracted the disease and that can help warn those who are at highest risk, the results do little to help prevent mesothelioma in people exposed to asbestos, a carcinogenic group of silicate minerals once used in a variety of construction and manufacturing processes.

Best case, the findings can help doctors select a treatment based on the knowledge a patient has a genetic predisposition. However, asbestos poses a cancer threat to anyone who inhales or ingests it—not just those who have a gene mutation. For this reason, anyone who may come in contact with any amount of asbestos should always take the utmost precautions to avoid exposure.

 

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