Inflammation prognostic indicator looks promising for mesothelioma patients

22 Sep 2017 by under News
Blausen 0676 Neutrophil crop 1 CREDIT BLAUSEN MEDICAL 100x100 Inflammation prognostic indicator looks promising for mesothelioma patients

Credit: Blausen Medical via Wikipedia

The neutrophil to lymphocyte ration (NLR) has been used as a prognostic indicator for patients with a number of cancers, but its benefits are still unclear for patients with malignant mesothelioma. Mesothelioma is a cancer of the lining of internal organs caused by exposure. It is usually deadly within 12-18 months of diagnosis and has few effective treatment options, prompting researchers to continue to find ways to help treat the disease and measure the effectiveness of those treatments.

In order help determine NLR’s promise as a diagnostic indicator for mesothelioma , researchers at China’s Sichuan University analyzed data from 11 studies, including 1,533 patients with pleural mesothelioma, according to Surviving Mesothelioma. The researchers’ findings aligned with those found for other types of cancers: outcomes were worse for patients with higher NLRs, calculated by dividing the of neutrophils in a blood sample by the number of lymphocytes.

Neutrophils are the most common form of white blood cell and lymphocytes are the primary form of white blood cell found in lymph, containing natural killer cells. NLR is used as an indicator of inflammation, according to the news source. Researchers also found a high NRL was linked to patients’ mesothelioma subtype.

“NLR level was also associated with histology instead of gender, stage or performance status (PS) score,” the study concludes. “These findings suggested that the elevated NLR could be a potential prognostic factor for malignant pleural mesothelioma patients and might be associated with histology as an efficient clinical index to stratify patients.”

 

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