New guidelines support chemotherapy as first-line treatment for pleural mesothelioma

4 May 2018 by under Research/Treatment

No new drugs have been approved fDiagram showing a build up of fluid in the lining of the lungs pleural effusion CRUK 0541 100x100 New guidelines support chemotherapy as first line treatment for pleural mesotheliomaor the treatment of malignant pleural mesothelioma (MPM) since 2004, but there have been significant advances in recent years in understanding the biology of the disease and identifying new targets for therapy, the American Society of Clinical Oncology (ASCO) announced.

Ongoing clinical trials show promising activity for the treatment of MPM, but the ASCO says these agents are not mature enough for the committee to recommend them. As a result, the ASCO, in its newly released clinical guidelines, supports chemotherapy as the mainstay of treatment for MPM, especially since surgery is not an option for most patients when they are diagnosed with the disease.

Patients for whom surgery is an option should follow multimodal therapy that involves chemotherapy with or without radiation therapy, the panel recommends.

“Given the rarity of this disease, there have been few large randomized trials, especially for surgical management of this disease,” the ASCO panel members wrote.

The recommendations, which are published in the Journal of Clinical Oncology, is the ASCO’s first guidelines for MPM. The guide covers all aspects of the disease, including diagnosis, staging, chemotherapy, surgery and radiation therapy.

MPM is the most common type of . It affects the pleura, or the lining that coats the lungs and chest wall. This rare form of lung cancer is caused by exposure. is a fibrous mineral found in rock and soil. It is used to make a variety of products from building materials to fire-resistant fabrics, and also has been found in talcum powders.

Source: MedPage Today

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