Posts Tagged ‘radiation’

Radiation therapy independently linked to developing mesothelioma

31 Jul 2017 by Sarah Mahan under Research/Treatment

120131 F ML202 100 1 100x100 Radiation therapy independently linked to developing mesotheliomaPeople who have received radiation to treat lymphoma have a greater chance of developing mesothelioma later in life, according to a new study conducted by Stanford Cancer Center and scientific consulting firm Exponent Inc. (more…)


IMRT proves effective mesothelioma treatment, study finds

25 Jul 2017 by Sarah Mahan under Research/Treatment
Przekrój ciała Pacjenta z rozkładem dawki promieniowania z nowotworem Głowy i Szyji leczonego techniką IMRT. 100x100 IMRT proves effective mesothelioma treatment, study finds

Morelmorel/Wikipedia

Intensity modulated radiation therapy (IMRT) is the most advanced type of radiation, allowing for even greater regulation of radiation beams than was possible in 3D planning. It’s a “sophisticated form of 3D planning,” according to OncoLink, and it is used regularly to treat a variety of cancers, including prostate cancer, gastrointestinal cancers, brain cancers and lung cancers.

IMRT has become increasingly important in the treatment of mesothelioma, a rare cancer caused by asbestos exposure that affects the lining of internal organs, but until recently, its benefits had never been proven, according to Surviving Mesothelioma. Dr. Kenneth Rosenzweig’s new study published in the Annals of Translational Medicine concludes IMRT at an experienced institution has led to improved mesothelioma outcomes and is “both feasible and effective” as a treatment option for malignant pleural mesothelioma(more…)


Cholesterol medication may help reduce healthy cell death in mesothelioma patients

6 Jun 2017 by Sarah Mahan under Research/Treatment

shutterstock 380260327 edited 100x100 Cholesterol medication may help reduce healthy cell death in mesothelioma patientsA cholesterol-lowering medication may be able to pull double duty to help mesothelioma patients, according to a group of Japanese researchers. The drug, pravastatin, has been shown to reduce damage to healthy cells when given to mice with mesothelioma before radiation treatments. (more…)


IMRT may be more effective mesothelioma radiation treatment

18 May 2017 by Sarah Mahan under Research/Treatment
RadiationTherapy 100x100 IMRT may be more effective mesothelioma radiation treatment

Credit: U.S. Air Force photo/ Staff Sgt. Liliana Moreno

Radiation therapy, or radiotherapy, is often included in the multi-modal treatment of mesothelioma, a deadly cancer caused by the inhalation or ingestion of asbestos. Because mesothelioma affects the lining of organs and those linings are in close contact with other vital tissues, radiation runs the risk of damaging surrounding healthy organs. New research has shown a different type of radiation therapy may be more effective on pleural mesothelioma, which affects the lining of the lungs, compared to standard conformal radiation by reducing the risk of damaging healthy tissue. (more…)


Australian doctor researching radiotherapy for treatment of pleural mesothelioma

9 Feb 2010 by Wendi Lewis under News, Research/Treatment

DrMalcolmFeigen 100x100 Australian doctor researching radiotherapy for treatment of pleural mesothelioma One of the many mesothelioma community members on Facebook posted a question today about a clinical trial being conducted at the Mesothelioma Center, located at New York-Presbyterian Hospital. MyMeso discussed this clinical trial in a July post. The clinical trial is a program of targeted radiation and chemotherapy protocol for pleural mesothelioma, which is a cancer of the lung’s lining almost always caused by asbestos. In response to the Facebook thread, meso survivor and awareness advocate (read: warrior) Debbie Brewer, who many of you know from her story and updates here (thanks Debbie!), mentioned a similar study currently ongoing in .

Debbie provided a link to a story published in November 2009 by ABC News that outlines the work of specialists at Austin Health Centre in Victoria. The treatment, spearheaded by Dr. Malcolm Feigen, a radiation oncologist at the Centre, uses high doses of radiotherapy, concentrated on specific areas of the lining of the lungs to target mesothelioma tumors.

According to the ABC report, 13 patients participated in a pilot program to test this new targeted radiotherapy treatment. Most had some surgery prior to the radiotherapy treatment, and some also had chemotherapy before or after the treatment, although Dr. Feigen believes the patients showed the most benefit primarily as a result of the radiotherapy regimen.

Participants in the U.S. clinical trial at the Mesothelioma Center receive a multi-modality therapy that incorporates surgery, chemotherapy and radiation therapy in combination.

Listen to the interview with Dr. Feigen about the Australian research, which was broadcast on ABC’s AM morning current affairs program.


Link between radiation and mesothelioma?

4 Jun 2009 by Wendi Lewis under News, Research/Treatment

A recent report published in blood, the Journal of the American Society of Hematology, is examining a possible increased risk for malignant mesothelioma among patients exposed to radiation treatment for Hodgkin lymphoma. According to the study, whose lead author is Marie L. DeBruin, increased risks for second primary mesothelioma after radiation for lymphoma have been reported. Mesothelioma is primarily related to asbestos exposure.

According to the journal summary, the findings are based on a small number of patients, so researchers are approaching these results with caution and anticipate more study to confirm the results. The team examined mesothelioma in 2,567 five-year survivors of Hodgkin lymphoma, who had been treated with radiation alone, chemotherapy alone, or a combination of the two.

The study indicated that mesothelioma risk was almost 30 times greater in Hodgkin lymphona patients treated with radiation than in the general population.

The journal article was summarized by HemOncToday, which reports clinical news in oncology and hematology. The publication says the median follow-up period for patients included in the radiation-mesothelioma study was 18.1 years, at which time researchers found 13 patients had malignant mesothelioma at least five years after being treated for Hodgkins lymphoma.

HemOncToday reports there were no cases of mesothelioma among patients treated with chemotherapy alone, but that patients treated with both radiation and chemotherapy were almost 44 times more likely to develop malignant mesothelioma.

Harry S. Jacob, MD, HemOncToday chief medical editor, provided this perspective:

“Seminal studies by Scripps Research Institute investigators demonstrated that asbestos with high-iron content (as opposed to low-Fe level asbestos) was more likely to cause mesotheliomas in miners. In vitro iron-asbestos promoted oxygen radical generation that altered DNA, providing rationale for the epidemiologic studies. The combination of radiation-mediated oxygen radicals plus lung iron asbestos (or tobacco-mediated iron deposition) may underlie these findings.”